LAMA4

Across TCGA patient cohorts, LAMA4 mutation is significantly associated with the RNA expression of many other genes, with 5,731 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAMA4-associated genes across cancer lineages are DGUOK, FGD5, and PIEZO2. Each is linked with LAMA4 in more than 5 cancer types. Because this analysis shows association rather than direction, both LAMA4-to-partner and partner-to-LAMA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DGUOK grouped by LAMA4-low versus LAMA4-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMA4→partner) and Y-score (partner→LAMA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DGUOK →	+0.285	+2.570	.001	<.001	3	6
STAD	FGD5 →	-0.836	-3.321	.001	.009	3	4
LUAD	PIEZO2 →	-0.575	-3.798	<.001	<.001	3	4
STAD	PLAC8L1 →	+0.442	+2.618	.002	.005	3	4
LUAD	LINC01311 →	+0.446	+3.953	<.001	<.001	3	4
LUAD	EMC3-AS1 →	+0.439	+2.137	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,731 associations by consensus.

DGUOK by LAMA4 expression — LUAD

Explore this box plot interactively →