LAMA4

Across TCGA patient cohorts, LAMA4 mutation is significantly associated with the total protein of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAMA4-associated genes across cancer lineages are JNK2, PCNA, and 4E-BP1. Each is linked with LAMA4 in more than 3 cancer types. Because this analysis shows association rather than direction, both LAMA4-to-partner and partner-to-LAMA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by LAMA4-low versus LAMA4-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMA4→partner) and Y-score (partner→LAMA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	JNK2 →	-0.126	-2.153	.026	.003	3	4
UCEC	PCNA →	+0.226	+1.662	<.001	<.001	3	4
LUAD	4E-BP1 →	+0.298	+1.749	.005	.049	3	4
UCEC	ASNS →	+0.269	+1.321	.003	.010	3	4
UCEC	Caspase-7-cleavedD198 →	+0.471	+1.135	.002	.014	3	4
LUAD	Ku80 →	+0.180	+1.448	.033	.027	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

JNK2 by LAMA4 expression — LUAD

Explore this box plot interactively →