LAMA4

Across TCGA cell cohorts, LAMA4 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,454 significant associations in total. BONE shows the largest number of these associations.

The most reproducible LAMA4-associated GO terms across cancer lineages are Regulation of cellular response to growth factor stimulus, Regulation of cell-substrate junction organization, and Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Each is linked with LAMA4 in more than 10 cancer types. Because this analysis shows association rather than direction, both LAMA4-to-partner and partner-to-LAMA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cellular response to growth factor stimulus grouped by LAMA4-low versus LAMA4-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMA4→partner) and Y-score (partner→LAMA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of cellular response to growth factor stimulus →	+0.071	+3.674	<.001	<.001	3	11
BONE	Regulation of cell-substrate junction organization →	+0.166	+3.992	<.001	<.001	3	11
BONE	Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway →	+0.060	+2.651	<.001	<.001	3	10
BONE	Positive regulation of cell-substrate junction organization →	+0.175	+2.943	<.001	<.001	3	10
BONE	Regulation of transforming growth factor beta receptor signaling pathway →	+0.072	+3.103	<.001	<.001	3	10
BONE	Establishment of protein localization to membrane →	+0.059	+2.571	.004	.003	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,454 associations by consensus.

Regulation of cellular response to growth factor stimulus by LAMA4 expression — SOFT_TISSUE

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