LAMA4

Across TCGA cell cohorts, LAMA4 mutation is significantly associated with the RNA expression of many other genes, with 489 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LAMA4-associated genes across cancer lineages are DYDC1, AADACL3, and LARP1B. Each is linked with LAMA4 in more than 2 cancer types. Because this analysis shows association rather than direction, both LAMA4-to-partner and partner-to-LAMA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DYDC1 grouped by LAMA4-low versus LAMA4-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMA4→partner) and Y-score (partner→LAMA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	DYDC1 →	+0.146	+4.906	<.001	.006	3	2
OESOPHAGUS	AADACL3 →	+0.410	+4.906	<.001	.006	3	2
LARGE_INTESTINE	LARP1B →	+0.726	+3.364	.001	.002	3	2
LARGE_INTESTINE	FEM1A →	+0.640	+3.169	<.001	.009	3	2
LARGE_INTESTINE	PSIP1 →	+0.678	+3.364	.009	.002	3	2
LARGE_INTESTINE	FGFBP3 →	+0.579	+3.364	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 489 associations by consensus.

DYDC1 by LAMA4 expression — OESOPHAGUS

Explore this box plot interactively →