Across TCGA patient cohorts, LAMA2 mutation is significantly associated with the RNA expression of many other genes, with 8,444 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAMA2-associated genes across cancer lineages are PGAM5, COX7A2, and AGPAT5. Each is linked with LAMA2 in more than 5 cancer types. Because this analysis shows association rather than direction, both LAMA2-to-partner and partner-to-LAMA2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMA2→partner) and Y-score (partner→LAMA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PGAM5 →	+0.460	+1.682	<.001	<.001	3	6
STAD	COX7A2 →	+0.403	+2.033	.001	.005	3	6
STAD	AGPAT5 →	+0.631	+2.519	<.001	.001	3	6
LUAD	POLE2 →	+0.371	+2.169	.003	<.001	3	6
UCEC	MAPKAPK5 →	+0.203	+1.024	.003	.009	3	6
LUAD	CDCA4 →	+0.376	+1.039	.002	.009	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,444 associations by consensus.

Exploration

LAMA2 survival (RNA) · tumor vs normal (RNA) · all LAMA2 data types