Across TCGA cell cohorts, LAMA2 mutation is significantly associated with the RNA expression of many other genes, with 2,677 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LAMA2-associated genes across cancer lineages are GATD3B, BCAS2, and ARL13B. Each is linked with LAMA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both LAMA2-to-partner and partner-to-LAMA2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMA2→partner) and Y-score (partner→LAMA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GATD3B →	-0.930	-2.402	.008	.008	3	3
LARGE_INTESTINE	BCAS2 →	+0.655	+2.906	<.001	<.001	3	3
LUNG_SCLC	ARL13B →	+0.566	+3.257	.002	.002	3	3
BLOOD_Leukemia	TMEM74 →	+0.402	+2.691	.004	.002	3	3
BLOOD_Leukemia	ZWILCH →	+0.472	+2.630	.005	.002	3	3
BLOOD_Leukemia	JAKMIP2 →	+0.951	+2.247	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,677 associations by consensus.

Exploration

LAMA2 survival (RNA) · tumor vs normal (RNA) · all LAMA2 data types