LAMA1

Across TCGA patient cohorts, LAMA1 mutation is significantly associated with the RNA expression of many other genes, with 11,396 significant associations in total. STAD shows the largest number of these associations.

The most reproducible LAMA1-associated genes across cancer lineages are FAM136A, RAI2, and SLC35B1. Each is linked with LAMA1 in more than 6 cancer types. Because this analysis shows association rather than direction, both LAMA1-to-partner and partner-to-LAMA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM136A grouped by LAMA1-low versus LAMA1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMA1→partner) and Y-score (partner→LAMA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	FAM136A →	+0.388	+4.120	<.001	<.001	3	7
STAD	RAI2 →	-1.154	-2.070	<.001	<.001	3	7
UCEC	SLC35B1 →	+0.289	+1.225	<.001	<.001	3	6
LUAD	ZWINT →	+0.623	+2.070	<.001	.001	3	6
LUAD	HROB →	+0.609	+2.158	<.001	<.001	3	6
LUAD	PIMREG →	+0.641	+1.699	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,396 associations by consensus.

FAM136A by LAMA1 expression — STAD

Explore this box plot interactively →