LAMA1

Across TCGA cell cohorts, LAMA1 mutation is significantly associated with the RNA expression of many other genes, with 3,039 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LAMA1-associated genes across cancer lineages are IRAK1BP1, OXA1L, and NOA1. Each is linked with LAMA1 in more than 4 cancer types. Because this analysis shows association rather than direction, both LAMA1-to-partner and partner-to-LAMA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IRAK1BP1 grouped by LAMA1-low versus LAMA1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMA1→partner) and Y-score (partner→LAMA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IRAK1BP1 →	+0.510	+1.808	.001	.001	3	4
LARGE_INTESTINE	OXA1L →	+0.375	+2.526	.001	.002	3	4
LARGE_INTESTINE	NOA1 →	+0.496	+2.807	<.001	<.001	3	4
BLOOD_Leukemia	SOCS4 →	+0.659	+1.936	<.001	.004	3	4
BLOOD_Leukemia	NPIPB11 →	+0.428	+1.936	.002	.004	2	5
LARGE_INTESTINE	STOX1 →	+1.014	+2.706	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,039 associations by consensus.

IRAK1BP1 by LAMA1 expression — LARGE_INTESTINE

Explore this box plot interactively →