LAIR2

Across TCGA patient cohorts, LAIR2 mutation is significantly associated with the RNA expression of many other genes, with 725 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAIR2-associated genes across cancer lineages are RN7SL785P, RNA5SP146, and IL6RP1. Each is linked with LAIR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LAIR2-to-partner and partner-to-LAIR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL785P grouped by LAIR2-low versus LAIR2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAIR2→partner) and Y-score (partner→LAIR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SL785P →	+0.364	+4.995	<.001	.009	3	2
LUAD	RNA5SP146 →	+0.234	+3.202	.004	.004	3	2
LUAD	IL6RP1 →	+0.032	+5.197	<.001	<.001	3	2
BLCA	OR5T3 →	+0.063	+6.466	<.001	<.001	3	2
BLCA	OR52M1 →	+0.042	+5.229	<.001	.002	3	2
UCEC	LINC02210 →	+0.514	+3.627	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 725 associations by consensus.

RN7SL785P by LAIR2 expression — BRCA

Explore this box plot interactively →