LAIR2

Across TCGA cell cohorts, LAIR2 mutation is significantly associated with the mutation status of many other genes, with 137 significant associations in total. CNS shows the largest number of these associations.

The most reproducible LAIR2-associated genes across cancer lineages are WDR47, SETD5, and LRRN2. Each is linked with LAIR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LAIR2-to-partner and partner-to-LAIR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WDR47 grouped by LAIR2-low versus LAIR2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAIR2→partner) and Y-score (partner→LAIR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	WDR47 →	+5.000	+4.044	.008	.008	1	2
CNS	SETD5 →	+3.000	+3.369	.008	.008	1	1
CNS	LRRN2 →	+5.000	+4.044	.008	.008	1	1
CNS	INSR →	+4.000	+4.000	.002	.002	1	1
CNS	KRT19 →	+5.000	+4.044	.008	.008	1	1
CNS	RXFP1 →	+5.000	+4.044	.008	.008	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 137 associations by consensus.

WDR47 by LAIR2 expression — CNS

Explore this box plot interactively →