LAIR1

Across TCGA patient cohorts, LAIR1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAIR1-associated genes across cancer lineages are Src_pY416, Acetyl-a-Tubulin-Lys40, and mTOR_pS2448. Each is linked with LAIR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LAIR1-to-partner and partner-to-LAIR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Src_pY416 grouped by LAIR1-low versus LAIR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAIR1→partner) and Y-score (partner→LAIR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Src_pY416 →	-0.252	-3.571	.030	.002	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.710	+3.584	.003	.002	3	1
UCEC	mTOR_pS2448 →	-0.198	-3.156	.006	.018	3	1
UCEC	Notch1 →	+0.164	+3.009	.015	.019	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.532	-3.169	.014	.019	3	1
UCEC	PCNA →	+0.280	+2.999	.007	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Src_pY416 by LAIR1 expression — UCEC

Explore this box plot interactively →