LAIR1

Across TCGA cell cohorts, LAIR1 mutation is significantly associated with the drug of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LAIR1-associated genes across cancer lineages are LCL161, 5-Fluorouracil, and UNC0642. Each is linked with LAIR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LAIR1-to-partner and partner-to-LAIR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCL161 grouped by LAIR1-low versus LAIR1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAIR1→partner) and Y-score (partner→LAIR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LCL161 →	+0.353	+2.646	.030	.047	3	2
LARGE_INTESTINE	5-Fluorouracil →	+0.580	+2.769	.046	.040	3	1
LARGE_INTESTINE	UNC0642 →	+0.233	+2.658	.012	.043	3	1
LARGE_INTESTINE	GSK2801 →	+0.345	+2.649	.030	.046	3	1
LARGE_INTESTINE	KRAS (G12C) Inhibitor-12 →	+0.626	+2.646	.011	.047	3	1
LARGE_INTESTINE	LIMK1 inhibitor BMS4 →	+0.390	+2.786	.029	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

LCL161 by LAIR1 expression — LARGE_INTESTINE

Explore this box plot interactively →