LAG3

Across TCGA patient cohorts, LAG3 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAG3-associated genes across cancer lineages are VHL, ATM, and Heregulin. Each is linked with LAG3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LAG3-to-partner and partner-to-LAG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by LAG3-low versus LAG3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAG3→partner) and Y-score (partner→LAG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.790	-1.807	.003	.025	3	2
UCEC	ATM →	-0.551	-2.415	.002	.003	3	2
UCEC	Heregulin →	-0.130	-2.308	.008	.033	3	1
UCEC	Ku80 →	+0.281	+1.498	.003	.036	3	1
UCEC	MEK1 →	+0.443	+2.700	.002	.006	3	1
UCEC	MSH2 →	-0.325	-1.848	<.001	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

VHL by LAG3 expression — UCEC

Explore this box plot interactively →