LAG3

Across TCGA cell cohorts, LAG3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,607 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible LAG3-associated GO terms across cancer lineages are Plasmacytoid dendritic cell activation, Regulation of microtubule-based process, and Positive regulation of DNA repair. Each is linked with LAG3 in more than 14 cancer types. Because this analysis shows association rather than direction, both LAG3-to-partner and partner-to-LAG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Plasmacytoid dendritic cell activation grouped by LAG3-low versus LAG3-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LAG3→partner) and Y-score (partner→LAG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Plasmacytoid dendritic cell activation →	-0.199	-0.557	.005	.007	2	15
BONE	Regulation of microtubule-based process →	+0.056	+0.991	<.001	<.001	3	11
STOMACH	Positive regulation of DNA repair →	+0.060	+0.482	.001	.009	3	11
STOMACH	Positive regulation of double-strand break repair →	+0.079	+0.535	.001	<.001	3	10
OVARY	Protein polymerization →	+0.068	+0.615	<.001	<.001	3	10
LUNG_NSCLC_LUSC	Locomotory exploration behavior →	+0.220	+0.652	.009	.008	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,607 associations by consensus.

Plasmacytoid dendritic cell activation by LAG3 expression — LIVER

Explore this box plot interactively →