LAG3

Across TCGA cell cohorts, LAG3 mutation is significantly associated with the mutation status of many other genes, with 874 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LAG3-associated genes across cancer lineages are ABCF2, E2F2, and GRB10. Each is linked with LAG3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LAG3-to-partner and partner-to-LAG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ABCF2 grouped by LAG3-low versus LAG3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAG3→partner) and Y-score (partner→LAG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ABCF2 →	+4.560	+4.309	.007	.007	1	2
BLOOD_Leukemia	E2F2 →	+3.560	+4.247	.002	.002	1	2
LUNG_NSCLC_LUAD	GRB10 →	+4.339	+4.339	.009	.009	1	2
BLOOD_Leukemia	CILK1 →	+5.560	+4.736	.003	.003	1	2
LUNG_NSCLC_LUAD	WNT5A →	+5.339	+4.772	.004	.004	1	2
LUNG_NSCLC_LUAD	ACAT2 →	+5.339	+4.772	.004	.004	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 874 associations by consensus.

ABCF2 by LAG3 expression — BLOOD_Leukemia

Explore this box plot interactively →