LAD1

Across TCGA pan-cancer cohorts, LAD1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated LAD1 data layer compared with 22 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher LAD1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated LAD1 expression acts as an unfavorable survival marker, although some lineages such as COAD and UCEC show a favorable association.

COAD, UCEC, and PDAC are the cancer types where LAD1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.887	.021	36	view →
UCEC	DFS	Tertile	All	0.970	0.764	.005	32	view →
PDAC	OS	Median	All	0.886	0.838	.029	7	view →
LUAD	OS	Tertile	All	1.000	0.953	.014	3	view →
HNSC	DFS	Median	All	0.985	0.919	.044	2	view →
CCRCC	OS	Tertile	All	1.000	0.896	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

LAD1–COAD (DFS)

Open the COAD breakdown →