LAD1

Across TCGA patient cohorts, LAD1 mutation is significantly associated with the RNA expression of many other genes, with 2,768 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAD1-associated genes across cancer lineages are MIR3978, IGHVII-46-1, and RNU7-197P. Each is linked with LAD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LAD1-to-partner and partner-to-LAD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3978 grouped by LAD1-low versus LAD1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAD1→partner) and Y-score (partner→LAD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR3978 →	+0.584	+5.251	.005	.003	3	3
LIHC	IGHVII-46-1 →	+0.809	+5.108	.001	.008	3	2
SKCM	RNU7-197P →	+0.141	+2.366	.006	.003	3	2
SKCM	RPL32P32 →	+0.406	+3.385	.003	.004	3	2
UCEC	DLAT →	+0.509	+1.847	.005	.009	3	2
UCEC	GUF1 →	+0.436	+2.246	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,768 associations by consensus.

MIR3978 by LAD1 expression — COAD

Explore this box plot interactively →