LAD1

Across TCGA patient cohorts, LAD1 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAD1-associated genes across cancer lineages are Cyclin-B1, Caspase-8, and mTOR_pS2448. Each is linked with LAD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LAD1-to-partner and partner-to-LAD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by LAD1-low versus LAD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAD1→partner) and Y-score (partner→LAD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.571	+2.584	.008	.001	3	3
UCEC	Caspase-8 →	-0.224	-2.673	.020	.005	3	2
UCEC	mTOR_pS2448 →	-0.130	-2.565	.023	.010	3	2
UCEC	PDCD4 →	-0.515	-2.087	.004	.005	3	2
UCEC	STAT3_pY705 →	-0.232	-1.874	.021	.049	3	2
SKCM	eEF2 →	+0.335	+2.459	.016	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Cyclin-B1 by LAD1 expression — UCEC

Explore this box plot interactively →