LAD1

Across TCGA cell cohorts, LAD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,001 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible LAD1-associated GO terms across cancer lineages are Serotonin secretion, Serotonin production involved in inflammatory response, and Serotonin secretion involved in inflammatory response. Each is linked with LAD1 in more than 10 cancer types. Because this analysis shows association rather than direction, both LAD1-to-partner and partner-to-LAD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Serotonin secretion grouped by LAD1-low versus LAD1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LAD1→partner) and Y-score (partner→LAD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Serotonin secretion →	+2.002	+4.666	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Serotonin production involved in inflammatory response →	+2.002	+4.666	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Serotonin secretion involved in inflammatory response →	+2.002	+4.666	<.001	<.001	3	11
URINARY_TRACT	Mammary gland development →	+0.174	+5.221	<.001	<.001	3	11
STOMACH	Maintenance of blood-brain barrier →	+0.219	+4.343	<.001	<.001	3	11
STOMACH	Cardiac conduction →	+0.190	+2.723	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,001 associations by consensus.

Serotonin secretion by LAD1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →