LACTB2

Across TCGA patient cohorts, LACTB2 mutation is significantly associated with the RNA expression of many other genes, with 203 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LACTB2-associated genes across cancer lineages are RN7SL515P, TUBB8P3, and OR11J5P. Each is linked with LACTB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LACTB2-to-partner and partner-to-LACTB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL515P grouped by LACTB2-low versus LACTB2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LACTB2→partner) and Y-score (partner→LACTB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SL515P →	+0.181	+4.628	<.001	.004	3	1
SKCM	TUBB8P3 →	+0.074	+5.682	<.001	<.001	3	1
BLCA	OR11J5P →	+0.059	+7.640	<.001	.009	3	1
BRCA	RNA5SP176 →	+0.189	+8.057	<.001	.005	3	1
BRCA	RN7SKP221 →	+0.065	+7.471	<.001	.008	3	1
BRCA	TRDD1 →	+0.910	+8.057	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 203 associations by consensus.

RN7SL515P by LACTB2 expression — SKCM

Explore this box plot interactively →