LACTB2

Across TCGA patient cohorts, LACTB2 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LACTB2-associated genes across cancer lineages are p62 Lck ligand, PAI-1, and 4E-BP1. Each is linked with LACTB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LACTB2-to-partner and partner-to-LACTB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by LACTB2-low versus LACTB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LACTB2→partner) and Y-score (partner→LACTB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.606	+3.179	<.001	.010	3	1
UCEC	PAI-1 →	+0.371	+3.169	.049	.020	3	1
UCEC	4E-BP1 →	+0.435	+3.169	.003	.020	3	1
UCEC	EGFR →	-0.198	-3.169	.024	.020	1	1
UCEC	eIF4E →	+0.255	+3.169	.027	.020	1	1
UCEC	MEK1 →	+0.460	+3.169	.021	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

p62 Lck ligand by LACTB2 expression — UCEC

Explore this box plot interactively →