LACTB2-AS1

Across TCGA pan-cancer cohorts, LACTB2-AS1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated LACTB2-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher LACTB2-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated LACTB2-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCS show a favorable association.

HNSC, UVM, and UCS are the cancer types where LACTB2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	II,III,IV	0.603	0.305	.001	81	view →
UVM	DFS	Quartile	III,IV	0.186	0.780	.002	78	view →
UCS	OS	Tertile	III,IV	0.859	0.400	.004	58	view →
KICH	OS	Tertile	III,IV	0.169	0.931	.001	55	view →
LGG	DFS	Median	All	0.640	0.820	<.001	54	view →
CESC	OS	Median	III,IV	0.803	0.506	.005	54	view →
KIRC	DFS	Median	All	0.811	0.913	.005	36	view →
COAD	DFS	Median	IV	0.332	0.621	.008	32	view →
LIHC	OS	Median	All	0.454	0.632	.014	19	view →
CHOL	OS	Median	All	0.923	0.573	.014	14	view →
BLCA	DFS	Quartile	All	0.622	0.367	.028	10	view →
THYM	OS	Median	All	1.000	0.670	.008	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

LACTB2-AS1–HNSC (OS)

Open the HNSC breakdown →