LACTB

Across TCGA cell cohorts, LACTB RNA expression is significantly associated with the go_rna of many other GO terms, with 5,947 significant associations in total. BONE shows the largest number of these associations.

The most reproducible LACTB-associated GO terms across cancer lineages are Positive regulation of corticotropin secretion, Regulation of corticotropin secretion, and PML body organization. Each is linked with LACTB in more than 14 cancer types. Because this analysis shows association rather than direction, both LACTB-to-partner and partner-to-LACTB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of corticotropin secretion grouped by LACTB-low versus LACTB-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LACTB→partner) and Y-score (partner→LACTB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of corticotropin secretion →	+1.377	+1.491	<.001	<.001	3	15
LUNG_NSCLC_LUSC	Regulation of corticotropin secretion →	+1.365	+1.885	.003	.001	3	14
LUNG_NSCLC_LUSC	PML body organization →	+0.235	+1.601	<.001	<.001	3	13
BLOOD_Lymphoma	Negative regulation of apoptotic signaling pathway →	+0.078	+1.912	<.001	<.001	3	12
BONE	Negative regulation of dendritic cell antigen processing and presentation →	+1.690	+1.923	<.001	<.001	3	12
BONE	Protein import into peroxisome membrane →	+0.116	+1.570	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,947 associations by consensus.

Positive regulation of corticotropin secretion by LACTB expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →