LACRT

Across TCGA patient cohorts, LACRT mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LACRT-associated genes across cancer lineages are eIF4G, FOXO3a, and GATA6. Each is linked with LACRT in more than 1 cancer types. Because this analysis shows association rather than direction, both LACRT-to-partner and partner-to-LACRT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by LACRT-low versus LACRT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LACRT→partner) and Y-score (partner→LACRT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.361	+2.321	.020	.035	3	1
UCEC	FOXO3a →	-0.134	-3.446	.008	.005	3	1
UCEC	GATA6 →	-0.188	-3.162	.026	.019	3	1
UCEC	IRS1 →	+0.213	+2.321	.040	.035	3	1
UCEC	JNK2 →	+0.277	+3.009	.005	.019	3	1
UCEC	Notch1 →	+0.163	+2.321	.021	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

eIF4G by LACRT expression — UCEC

Explore this box plot interactively →