LACC1

Across TCGA patient cohorts, LACC1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LACC1-associated genes across cancer lineages are JNK_pT183_Y185, JNK2, and mTOR. Each is linked with LACC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LACC1-to-partner and partner-to-LACC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by LACC1-low versus LACC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LACC1→partner) and Y-score (partner→LACC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.218	-3.156	.018	.020	3	1
UCEC	JNK2 →	+0.273	+3.169	.012	.020	3	1
UCEC	mTOR →	-0.233	-3.169	.008	.020	3	1
UCEC	Rab25 →	-0.538	-3.169	.003	.020	3	1
UCEC	Stathmin →	+0.172	+2.833	.022	.034	3	1
UCEC	VHL →	-1.269	-3.169	<.001	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

JNK_pT183_Y185 by LACC1 expression — UCEC

Explore this box plot interactively →