L3MBTL4

Across TCGA pan-cancer cohorts, L3MBTL4 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated L3MBTL4 data layer compared with 21 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher L3MBTL4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated L3MBTL4 expression acts as an unfavorable survival marker.

BLCA, LGG, and COAD are the cancer types where L3MBTL4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	III,IV	0.193	0.658	<.001	41	view →
LGG	DFS	Median	All	0.142	0.738	<.001	6	view →
COAD	DFS	Median	II,III,IV	0.234	0.687	.022	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

L3MBTL4–BLCA (OS)

Open the BLCA breakdown →