L3MBTL4

Across TCGA patient cohorts, L3MBTL4 mutation is significantly associated with the RNA expression of many other genes, with 3,605 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible L3MBTL4-associated genes across cancer lineages are TUFM, DCTPP1, and GPATCH3. Each is linked with L3MBTL4 in more than 2 cancer types. Because this analysis shows association rather than direction, both L3MBTL4-to-partner and partner-to-L3MBTL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TUFM grouped by L3MBTL4-low versus L3MBTL4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (L3MBTL4→partner) and Y-score (partner→L3MBTL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TUFM →	+0.324	+2.148	.006	<.001	3	3
UCEC	DCTPP1 →	+0.573	+1.818	.001	.002	3	3
UCEC	GPATCH3 →	+0.392	+3.023	<.001	<.001	3	3
UCEC	CCDC86 →	+0.411	+2.637	.007	.005	3	3
UCEC	IMMP1L →	+0.376	+1.818	.002	.002	3	2
UCEC	HIRIP3 →	+0.404	+2.939	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,605 associations by consensus.

TUFM by L3MBTL4 expression — UCEC

Explore this box plot interactively →