L3MBTL4

Across TCGA patient cohorts, L3MBTL4 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible L3MBTL4-associated genes across cancer lineages are eIF4E, Caspase-7-cleavedD198, and Ku80. Each is linked with L3MBTL4 in more than 2 cancer types. Because this analysis shows association rather than direction, both L3MBTL4-to-partner and partner-to-L3MBTL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by L3MBTL4-low versus L3MBTL4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (L3MBTL4→partner) and Y-score (partner→L3MBTL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eIF4E →	+0.308	+2.820	<.001	.035	3	3
COAD	Caspase-7-cleavedD198 →	+1.609	+3.178	<.001	.010	3	3
UCEC	Ku80 →	+0.198	+1.515	.022	.018	3	3
SKCM	Caveolin-1 →	-0.686	-2.000	.004	.029	3	2
COAD	Akt_pS473 →	-0.599	-3.161	.005	.019	3	2
COAD	PKC-b-II_pS660 →	-0.426	-3.161	.014	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

eIF4E by L3MBTL4 expression — COAD

Explore this box plot interactively →