L3MBTL4

Across TCGA cell cohorts, L3MBTL4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,404 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible L3MBTL4-associated GO terms across cancer lineages are Regulation of translational initiation, Protein K48-linked ubiquitination, and Cytoplasmic translation. Each is linked with L3MBTL4 in more than 7 cancer types. Because this analysis shows association rather than direction, both L3MBTL4-to-partner and partner-to-L3MBTL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of translational initiation grouped by L3MBTL4-low versus L3MBTL4-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (L3MBTL4→partner) and Y-score (partner→L3MBTL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Regulation of translational initiation →	+0.061	+0.817	<.001	<.001	3	8
OESOPHAGUS	Protein K48-linked ubiquitination →	+0.075	+0.979	<.001	.001	3	7
OESOPHAGUS	Cytoplasmic translation →	+0.097	+0.748	<.001	.001	3	7
PANCREAS	Regulation of protein modification by small protein conjugation or removal →	+0.055	+0.965	<.001	.003	3	7
PANCREAS	Regulation of DNA-templated transcription elongation →	+0.042	+0.696	<.001	.001	3	7
BLOOD_Leukemia	CD8-positive, alpha-beta T cell homeostasis →	+0.084	+0.657	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,404 associations by consensus.

Regulation of translational initiation by L3MBTL4 expression — CNS

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