Across TCGA pan-cancer cohorts, L3MBTL3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated L3MBTL3 data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher L3MBTL3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated L3MBTL3 expression acts as an unfavorable survival marker.

HNSC, UCEC, and CCRCC are the cancer types where L3MBTL3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.226	1.000	<.001	79	view →
UCEC	OS	Tertile	II,III,IV	0.495	1.000	.007	16	view →
CCRCC	OS	Median	IV	0.204	1.000	.014	10	view →
PDAC	OS	Quartile	All	0.268	0.463	.023	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: L3MBTL3 tumor-vs-normal RNA expression · all L3MBTL3 data types