Across TCGA patient cohorts, L3MBTL3 protein abundance is significantly associated with the RNA expression of many other genes, with 11,169 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible L3MBTL3-associated genes across cancer lineages are PROX1, GPR161, and STAG1. Each is linked with L3MBTL3 in more than 4 cancer types. Because this analysis shows association rather than direction, both L3MBTL3-to-partner and partner-to-L3MBTL3 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (L3MBTL3→partner) and Y-score (partner→L3MBTL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PROX1 →	+1.332	+0.262	.003	.002	3	5
LSCC	GPR161 →	+0.975	+0.291	<.001	<.001	3	5
LSCC	STAG1 →	+0.652	+0.302	<.001	<.001	3	4
UCEC	RSPO3 →	+1.310	+0.282	<.001	.001	3	4
LSCC	CCDC50 →	+0.768	+0.290	<.001	<.001	3	4
LSCC	SV2A →	+0.977	+0.337	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,169 associations by consensus.

Exploration

L3MBTL3 survival (RNA) · tumor vs normal (RNA) · all L3MBTL3 data types