Across TCGA patient cohorts, L3MBTL3 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible L3MBTL3-associated genes across cancer lineages are Shc_pY317, ASNS, and Notch1. Each is linked with L3MBTL3 in more than 2 cancer types. Because this analysis shows association rather than direction, both L3MBTL3-to-partner and partner-to-L3MBTL3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (L3MBTL3→partner) and Y-score (partner→L3MBTL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.155	-2.222	.003	.010	3	3
COAD	ASNS →	+0.640	+3.000	<.001	.035	3	3
UCEC	Notch1 →	+0.177	+1.662	<.001	.011	3	2
UCEC	p27_pT198 →	+0.078	+1.362	.038	.037	3	2
UCEC	Annexin_VII →	-0.123	-1.990	.012	.030	3	2
UCEC	STAT3_pY705 →	-0.378	-2.000	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Exploration

L3MBTL3 survival (RNA) · tumor vs normal (RNA) · all L3MBTL3 data types