L3MBTL2

Across TCGA patient cohorts, L3MBTL2 RNA expression is significantly associated with the mutation status of many other genes, with 11,556 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible L3MBTL2-associated genes across cancer lineages are NCOR1, EP300, and BAHCC1. Each is linked with L3MBTL2 in more than 4 cancer types. Because this analysis shows association rather than direction, both L3MBTL2-to-partner and partner-to-L3MBTL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NCOR1 grouped by L3MBTL2-low versus L3MBTL2-high in COAD.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (L3MBTL2→partner) and Y-score (partner→L3MBTL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	NCOR1 →	+2.249	+0.245	.005	.003	3	5
COAD	EP300 →	+3.486	+0.346	.002	<.001	3	4
CESC	BAHCC1 →	+2.411	+0.366	.002	.001	3	4
LUSC	IPO8 →	+2.724	+0.370	.003	.002	3	4
UCEC	FAM135B →	+1.294	+0.262	<.001	<.001	3	4
LIHC	OBSCN →	+2.694	+0.309	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,556 associations by consensus.

NCOR1 by L3MBTL2 expression — COAD

Explore this box plot interactively →