L3MBTL2

Across TCGA patient cohorts, L3MBTL2 mutation is significantly associated with the RNA expression of many other genes, with 1,304 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible L3MBTL2-associated genes across cancer lineages are TRAJ47, MIR4779, and MCAT. Each is linked with L3MBTL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both L3MBTL2-to-partner and partner-to-L3MBTL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ47 grouped by L3MBTL2-low versus L3MBTL2-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (L3MBTL2→partner) and Y-score (partner→L3MBTL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TRAJ47 →	+0.612	+5.124	<.001	.008	3	3
CESC	MIR4779 →	+0.334	+3.922	<.001	.003	3	3
UCEC	MCAT →	+0.370	+2.265	.001	.005	3	2
UCEC	OAZ1 →	+0.496	+4.247	<.001	<.001	3	2
UCEC	TIMM44 →	+0.359	+2.364	<.001	.002	3	2
UCEC	MLX →	+0.392	+2.743	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,304 associations by consensus.

TRAJ47 by L3MBTL2 expression — HNSC

Explore this box plot interactively →