L3MBTL2

Across TCGA patient cohorts, L3MBTL2 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible L3MBTL2-associated genes across cancer lineages are Caspase-7-cleavedD198, p90 RSK, and PCNA. Each is linked with L3MBTL2 in more than 3 cancer types. Because this analysis shows association rather than direction, both L3MBTL2-to-partner and partner-to-L3MBTL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by L3MBTL2-low versus L3MBTL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (L3MBTL2→partner) and Y-score (partner→L3MBTL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.705	+2.341	.001	.003	3	4
UCEC	p90 RSK →	+0.171	+2.321	.015	.033	3	2
UCEC	PCNA →	+0.219	+1.847	.005	.008	3	2
UCEC	Rictor_pT1135 →	-0.088	-2.000	.019	.030	3	2
UCEC	ATM →	-0.378	-2.308	.023	.033	3	2
UCEC	Caveolin-1 →	-0.557	-2.584	.036	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Caspase-7-cleavedD198 by L3MBTL2 expression — UCEC

Explore this box plot interactively →