L3MBTL2

Across TCGA cell cohorts, L3MBTL2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,582 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible L3MBTL2-associated GO terms across cancer lineages are Negative regulation of chromosome condensation, Symbiont-mediated disruption of host cellular anatomical structure, and Symbiont-mediated disruption of host anatomical structure. Each is linked with L3MBTL2 in more than 15 cancer types. Because this analysis shows association rather than direction, both L3MBTL2-to-partner and partner-to-L3MBTL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of chromosome condensation grouped by L3MBTL2-low versus L3MBTL2-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (L3MBTL2→partner) and Y-score (partner→L3MBTL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Negative regulation of chromosome condensation →	+0.170	+0.705	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Symbiont-mediated disruption of host cellular anatomical structure →	+0.133	+0.763	<.001	.001	3	15
UPPER_AERODIGESTIVE_TRACT	Symbiont-mediated disruption of host anatomical structure →	+0.133	+0.763	<.001	.001	3	15
BONE	Regulation of chromatin organization →	+0.119	+0.607	<.001	<.001	3	14
PANCREAS	Cell cycle checkpoint signaling →	+0.070	+0.593	.002	.004	3	14
KIDNEY	Positive regulation of cell fate commitment →	+0.243	+0.892	<.001	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,582 associations by consensus.

Negative regulation of chromosome condensation by L3MBTL2 expression — OVARY

Explore this box plot interactively →