L3MBTL2

Across TCGA cell cohorts, L3MBTL2 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible L3MBTL2-associated genes across cancer lineages are PHOX2B, FAM205A, and GSG1L2. Each is linked with L3MBTL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both L3MBTL2-to-partner and partner-to-L3MBTL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PHOX2B grouped by L3MBTL2-low versus L3MBTL2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (L3MBTL2→partner) and Y-score (partner→L3MBTL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PHOX2B →	+0.024	+3.658	.004	.005	3	1
LARGE_INTESTINE	FAM205A →	+0.019	+3.766	.001	.004	3	1
LARGE_INTESTINE	GSG1L2 →	+0.013	+4.022	<.001	.006	3	1
BLOOD_Leukemia	IL4 →	+2.137	+4.007	<.001	.002	3	1
BLOOD_Leukemia	HRG →	+0.305	+4.177	<.001	.001	3	1
BLOOD_Leukemia	C20orf85 →	+0.015	+3.969	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

PHOX2B by L3MBTL2 expression — LARGE_INTESTINE

Explore this box plot interactively →