L3HYPDH

Across TCGA pan-cancer cohorts, L3HYPDH mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated L3HYPDH data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher L3HYPDH mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated L3HYPDH expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

LSCC, COAD, and GBM are the cancer types where L3HYPDH mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	II,III,IV	0.598	0.928	.001	53	view →
COAD	DFS	Median	III,IV	0.829	1.000	.027	12	view →
GBM	DFS	Quartile	All	0.602	0.838	.006	8	view →
CCRCC	DFS	Quartile	III,IV	0.927	0.462	.019	5	view →
UCEC	OS	Tertile	III,IV	0.502	1.000	.042	4	view →
HNSC	DFS	Quartile	IV	0.886	0.583	.030	4	view →
LUAD	DFS	Quartile	All	0.423	0.896	.021	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

L3HYPDH–LSCC (OS)

Open the LSCC breakdown →