L3HYPDH

Across TCGA patient cohorts, L3HYPDH RNA expression is significantly associated with the protein abundance of many other proteins, with 11,201 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible L3HYPDH-associated proteins across cancer lineages are NEK9, SEC23B, and SPCS3. Each is linked with L3HYPDH in more than 4 cancer types. Because this analysis shows association rather than direction, both L3HYPDH-to-partner and partner-to-L3HYPDH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, L3HYPDH versus NEK9 in GBM, with a Pearson correlation of 0.38.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (L3HYPDH→partner) and Y-score (partner→L3HYPDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NEK9 →	+0.312	+0.596	<.001	<.001	3	5
LUAD	SEC23B →	-0.330	-0.490	<.001	<.001	3	5
LSCC	SPCS3 →	-0.546	-0.512	<.001	<.001	3	5
GBM	DNTTIP1 →	+0.227	+0.428	<.001	<.001	3	5
LSCC	TRMT5 →	+0.291	+0.490	<.001	<.001	3	5
COAD	OLFML3 →	+0.625	+0.528	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,201 associations by consensus.

L3HYPDH vs NEK9 — GBM

Explore this scatter interactively →