L3HYPDH

Across TCGA patient cohorts, L3HYPDH protein abundance is significantly associated with the RNA expression of many other genes, with 19,288 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible L3HYPDH-associated genes across cancer lineages are PRKG1, COLEC12, and DACT1. Each is linked with L3HYPDH in more than 8 cancer types. Because this analysis shows association rather than direction, both L3HYPDH-to-partner and partner-to-L3HYPDH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, L3HYPDH versus PRKG1 in UCEC, with a Pearson correlation of 0.64.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (L3HYPDH→partner) and Y-score (partner→L3HYPDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRKG1 →	+1.054	+0.534	<.001	<.001	3	9
COAD	COLEC12 →	+1.029	+0.359	<.001	<.001	3	9
OV	DACT1 →	+1.143	+0.419	<.001	<.001	3	8
BRCA	FERMT2 →	+1.029	+0.460	<.001	<.001	3	8
COAD	GGT5 →	+1.169	+0.534	<.001	<.001	3	8
OV	IFFO1 →	+0.919	+0.466	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,288 associations by consensus.

L3HYPDH vs PRKG1 — UCEC

Explore this scatter interactively →