L3HYPDH

Across TCGA patient cohorts, L3HYPDH mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible L3HYPDH-associated genes across cancer lineages are Ku80, mTOR, and Notch1. Each is linked with L3HYPDH in more than 1 cancer types. Because this analysis shows association rather than direction, both L3HYPDH-to-partner and partner-to-L3HYPDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by L3HYPDH-low versus L3HYPDH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (L3HYPDH→partner) and Y-score (partner→L3HYPDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.313	+3.013	.021	.019	3	1
UCEC	mTOR →	-0.303	-3.000	.001	.037	3	1
UCEC	Notch1 →	+0.247	+2.817	.002	.036	3	1
UCEC	PDCD4 →	-0.796	-3.000	.003	.037	3	1
UCEC	Rab25 →	-0.590	-3.000	.002	.037	3	1
UCEC	AR →	-0.437	-3.000	.043	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Ku80 by L3HYPDH expression — UCEC

Explore this box plot interactively →