L3HYPDH

Across TCGA cell cohorts, L3HYPDH RNA expression is significantly associated with the go_rna of many other GO terms, with 4,359 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible L3HYPDH-associated GO terms across cancer lineages are Positive regulation of focal adhesion assembly, Regulation of cell-substrate junction organization, and Positive regulation of cell-substrate junction organization. Each is linked with L3HYPDH in more than 13 cancer types. Because this analysis shows association rather than direction, both L3HYPDH-to-partner and partner-to-L3HYPDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of focal adhesion assembly grouped by L3HYPDH-low versus L3HYPDH-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (L3HYPDH→partner) and Y-score (partner→L3HYPDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of focal adhesion assembly →	+0.211	+1.263	.001	.002	3	14
SKIN	Regulation of cell-substrate junction organization →	+0.077	+0.910	<.001	<.001	3	13
BONE	Positive regulation of cell-substrate junction organization →	+0.193	+1.928	<.001	<.001	3	13
LARGE_INTESTINE	Microtubule nucleation →	+0.134	+1.156	<.001	<.001	3	12
LIVER	Caveola assembly →	+0.287	+1.158	<.001	.005	3	12
UPPER_AERODIGESTIVE_TRACT	Regulation of cilium assembly →	+0.064	+1.053	<.001	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,359 associations by consensus.

Positive regulation of focal adhesion assembly by L3HYPDH expression — BONE

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