L3HYPDH

Across TCGA cell cohorts, L3HYPDH mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible L3HYPDH-associated genes across cancer lineages are OR10G7, MAGEB4, and HSFY2. Each is linked with L3HYPDH in more than 1 cancer types. Because this analysis shows association rather than direction, both L3HYPDH-to-partner and partner-to-L3HYPDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10G7 grouped by L3HYPDH-low versus L3HYPDH-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (L3HYPDH→partner) and Y-score (partner→L3HYPDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR10G7 →	+0.033	+5.029	<.001	.006	3	1
LARGE_INTESTINE	MAGEB4 →	+0.012	+5.415	.009	.004	3	1
LARGE_INTESTINE	HSFY2 →	+0.023	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

OR10G7 by L3HYPDH expression — LUNG_SCLC

Explore this box plot interactively →