L2HGDH

Across TCGA patient cohorts, L2HGDH protein abundance is significantly associated with the RNA expression of many other genes, with 14,091 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible L2HGDH-associated genes across cancer lineages are ARHGAP5, DSE, and ARHGAP9. Each is linked with L2HGDH in more than 5 cancer types. Because this analysis shows association rather than direction, both L2HGDH-to-partner and partner-to-L2HGDH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, L2HGDH versus ARHGAP5 in HNSC, with a Pearson correlation of 0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (L2HGDH→partner) and Y-score (partner→L2HGDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ARHGAP5 →	+0.772	+0.390	<.001	<.001	3	6
LSCC	DSE →	-0.573	-0.400	<.001	<.001	3	6
BRCA	ARHGAP9 →	-0.814	-0.354	<.001	.002	3	6
GBM	GLIPR1 →	-0.737	-0.268	<.001	<.001	3	6
BRCA	CMTM3 →	-0.961	-0.451	<.001	<.001	3	6
CCRCC	C1S →	-0.986	-0.334	.007	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,091 associations by consensus.

L2HGDH vs ARHGAP5 — HNSC

Explore this scatter interactively →