L2HGDH

Across TCGA patient cohorts, L2HGDH mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible L2HGDH-associated genes across cancer lineages are TFRC, Tuberin_pT1462, and ASNS. Each is linked with L2HGDH in more than 1 cancer types. Because this analysis shows association rather than direction, both L2HGDH-to-partner and partner-to-L2HGDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by L2HGDH-low versus L2HGDH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (L2HGDH→partner) and Y-score (partner→L2HGDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.598	+2.000	.012	.032	3	2
UCEC	Tuberin_pT1462 →	+0.262	+2.700	.011	.006	3	2
UCEC	ASNS →	+0.597	+2.584	<.001	.010	3	2
UCEC	Cyclin-B1 →	+0.657	+3.321	.009	.010	3	2
UCEC	EGFR_pY1068 →	-0.334	-3.321	.003	.010	3	1
UCEC	A-Raf_pS299 →	-0.119	-2.459	.026	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

TFRC by L2HGDH expression — UCEC

Explore this box plot interactively →