L2HGDH

Across TCGA cell cohorts, L2HGDH RNA expression is significantly associated with the go_rna of many other GO terms, with 4,770 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible L2HGDH-associated GO terms across cancer lineages are DNA strand elongation, Cell cycle phase transition, and Mitotic DNA integrity checkpoint signaling. Each is linked with L2HGDH in more than 15 cancer types. Because this analysis shows association rather than direction, both L2HGDH-to-partner and partner-to-L2HGDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA strand elongation grouped by L2HGDH-low versus L2HGDH-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (L2HGDH→partner) and Y-score (partner→L2HGDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNA strand elongation →	+0.176	+1.381	<.001	<.001	3	16
BONE	Cell cycle phase transition →	+0.093	+1.131	.008	.003	3	16
BLOOD_Myeloma	Mitotic DNA integrity checkpoint signaling →	+0.072	+0.892	.003	.004	3	16
BONE	DNA-templated DNA replication maintenance of fidelity →	+0.104	+1.103	.006	<.001	3	16
BONE	DNA-templated DNA replication →	+0.120	+1.042	.004	<.001	3	16
PANCREAS	Positive regulation of DNA-directed DNA polymerase activity →	+0.191	+1.475	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,770 associations by consensus.

DNA strand elongation by L2HGDH expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →