Across TCGA pan-cancer cohorts, L1CAM mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated L1CAM data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher L1CAM mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated L1CAM expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

UCEC, PDAC, and HNSC are the cancer types where L1CAM mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	All	0.805	1.000	.010	26	view →
PDAC	OS	Median	All	0.417	0.724	.002	10	view →
HNSC	OS	Quartile	II,III,IV	0.921	1.000	.022	5	view →
LUAD	DFS	Median	III,IV	0.400	0.916	.020	4	view →
GBM	DFS	Median	All	0.817	0.674	.027	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: L1CAM tumor-vs-normal RNA expression · all L1CAM data types