Across TCGA patient cohorts, L1CAM protein abundance is significantly associated with the RNA expression of many other genes, with 9,419 significant associations in total. GBM shows the largest number of these associations.

The most reproducible L1CAM-associated genes across cancer lineages are DIRAS1, SLC6A15, and OPTN. Each is linked with L1CAM in more than 4 cancer types. Because this analysis shows association rather than direction, both L1CAM-to-partner and partner-to-L1CAM results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (L1CAM→partner) and Y-score (partner→L1CAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DIRAS1 →	+1.552	+0.810	<.001	.006	3	5
GBM	SLC6A15 →	+1.056	+0.909	<.001	<.001	3	5
BRCA	OPTN →	+0.967	+0.806	<.001	.003	3	5
HNSC	VEGFC →	+1.578	+0.480	<.001	<.001	3	4
GBM	KIF5A →	+1.291	+0.882	<.001	<.001	3	4
COAD	GREM1 →	+0.988	+0.425	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,419 associations by consensus.

Exploration

L1CAM survival (RNA) · tumor vs normal (RNA) · all L1CAM data types