Across TCGA patient cohorts, L1CAM mutation is significantly associated with the RNA expression of many other genes, with 5,653 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible L1CAM-associated genes across cancer lineages are PCGF6, AUNIP, and SKA1. Each is linked with L1CAM in more than 4 cancer types. Because this analysis shows association rather than direction, both L1CAM-to-partner and partner-to-L1CAM results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (L1CAM→partner) and Y-score (partner→L1CAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PCGF6 →	+0.515	+1.983	.001	.002	3	5
LUAD	AUNIP →	+0.497	+2.011	.008	.001	3	4
LUAD	SKA1 →	+0.613	+2.819	.006	.001	3	4
COAD	KIF11 →	+0.547	+2.605	.004	.005	3	4
COAD	PBK →	+0.829	+3.615	<.001	.001	3	4
STAD	SPATA5L1 →	+0.463	+3.584	.006	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,653 associations by consensus.

Exploration

L1CAM survival (RNA) · tumor vs normal (RNA) · all L1CAM data types