Across TCGA patient cohorts, L1CAM mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible L1CAM-associated genes across cancer lineages are Caspase-7-cleavedD198, TFRC, and p38-MAPK_pT180_Y182. Each is linked with L1CAM in more than 4 cancer types. Because this analysis shows association rather than direction, both L1CAM-to-partner and partner-to-L1CAM results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (L1CAM→partner) and Y-score (partner→L1CAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.545	+1.604	<.001	.001	3	5
STAD	TFRC →	+0.729	+3.321	.012	.010	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.290	-1.295	.009	.008	3	3
UCEC	c-Kit →	-0.126	-1.275	.029	.008	3	3
UCEC	Cyclin-B1 →	+0.458	+1.584	.001	.002	3	3
STAD	ERK2 →	+0.330	+3.321	.023	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

Exploration

L1CAM survival (RNA) · tumor vs normal (RNA) · all L1CAM data types